Juventus and Inter have both won three of their last four games, and have scored just two goals in the past three.
However, this time around, the Serie A giants have a big advantage.
They will face off in a match that will decide who ends up with the last two points in their Champions League group.
With the Bianconeri currently without a win in their last six matches, they are only four points clear of second-placed Juventus and four ahead of the Italian champions.
The Biancones are currently tied with Lazio for the title, with the Biancocelesti sitting just three points behind.
What will Juventus do?
They have not lost a Serie A game this season, winning three, drawing one and drawing the other.
Inter, meanwhile, have won three, drawn two and lost two, all in Serie B. This will be their fifth Serie B match, with Inter last winning in their previous eight.
The game kicks off at 17:00 GMT on Tuesday, with kick-off at 18:00.
Who will score?
Juventus, the reigning Serie A champions, will be hoping to score their second consecutive league goal in the first leg.
They are unbeaten in their past eight games, with all three goals coming in the last eight minutes.
Inter are not as lucky, with just one goal scored in the final 15 minutes of their matches.
Juve have scored two goals against Inter so far this season.
Where will Juventas goals come from?
Juve will look to put away Inter at the Stadio Olimpico, while Inter will look for a goal in extra time.
Who’s on the score sheet?
Inter are unbeaten at home in Serie A this season (0-0).
Juventus have only lost once at home to Inter, in November.